Three independent clinical evaluations document bActivate's efficacy. At Hagyard Equine Medical Institute (Lexington, KY), Dr. Kristina Lu treated 64 problem mares — 83% became pregnant. At Kildangan Stud, operated by Godolphin, 89% of 19 problem mares achieved pregnancy. A collaborative study between Copenhagen University and the Breeders Club reported a 72% live foal rate across treated mares. All three studies were conducted independently of the manufacturer.
Hidden infections. Persistent infertility. Missed opportunities. For too long, problem mares—those with recurring fertility issues—have faced unseen barriers to reproduction.
Below studies show that 80% of these mares harbor hidden uterine infections that traditional tests fail to detect, making pregnancy an uphill battle.
This collection introduces a breakthrough: bActivate. By reactivating dormant Streptococcus equi subsp. zooepidemicus, the most common cause of chronic uterine infections, bActivate uncovers what was once invisible. For the first time, veterinarians can accurately diagnose and effectively treat these elusive infections.
Supported by our studies and real-world evidence, this body of work repeatedly demonstrates the profound success of bActivate in restoring fertility in problem mares. With proven results, practical solutions, and renewed hope, this is a roadmap for transforming equine reproductive health.
Step into a future where no infection stays hidden, and no mare is left behind.
bActivate is independently referenced by the world's most respected equine veterinary publications and research institutions.
"...a (growth medium) product called bActivate, which activates dormant Streptococcus that can live within the endometrium, stimulating them to become metabolically active so we can treat them."
"Infusion of Bactivate when the mare is in estrus activates the dormant B.strep, increasing replication and growth, providing identification at 24 hours."
"Most of the mares (83%) became pregnant within 6 weeks, and a majority of those gave birth to live foals." — Study of 64 broodmares treated with bActivate.
"72% of problem mares achieved live foals the year after activation. 84% of participating mares had a latent streptococcal infection."
"Knap 10% af hopperne bliver aldrig drægtige trods dyrlægehjælp. Bactivate vækker sovende bakterier, så de kan diagnosticeres og behandles effektivt med antibiotika."
"bActivate — a growth medium specifically formulated to reactivate dormant Strep uterine infections — demonstrated effectiveness: treated mares showed only 8% bacterial positivity versus 64% in control animals."
A veterinary thesis from the University of Copenhagen, Department of Veterinary and Animal Sciences, supervised by Prof. Anders Miki Bojesen. The study investigated the role of subclinical Streptococcus equi subsp. zooepidemicus infection in 31 problem mares from Ireland and Denmark — combining bacteriology, histology (Kenney-score), and Fluorescence In Situ Hybridization (FISH).
Conclusion: Subclinical S. zooepidemicus infection has a markedly negative impact on fertility in mares — but this effect can be reversed by activation with bActivate and targeted antibiotic treatment.
This document showcases advancements in diagnosing and treating latent endometritis in mares, supported by leading equine specialists such as Dr. Kristina Lu and the theriogenology team at Hagyard Equine Medical Institute. Their work with innovative tools bActivate has transformed the management of dormant infections, enabling precise diagnosis and successful treatment. A total of 64 problem mares were included and subsequently bred. Pregnancy was established in 53 (83%) mares
This study investigates the impact of latent infections caused by Streptococcus equi subsp. zooepidemicus on fertility in mares. Dormant bacteria are shown to persist intracellularly within the uterus, evading detection by traditional methods. These infections disrupt the establishment and maintenance of pregnancy, highlighting the necessity for advanced diagnostic tools like bActivate, which enables the detection and effective treatment of dormant infections.
In 19 problem mares treated at Kildangan Stud, 89% achieved pregnancy.
Conclusion
Latent infections significantly reduce fertility in mares, with dormant bacteria negatively affecting pregnancy outcomes. The use of bActivate dramatically improves diagnostic accuracy and treatment success, leading to enhanced reproductive performance.
This study explores how Streptococcus equi subsp. zooepidemicus invades and survives within epithelial cells, contributing to latent endometritis in mares. The research, led by Associate Professor Bolette Skive and Professor Manfred Rohde, reveals three distinct bacterial invasion mechanisms.
This study examines antimicrobial tolerance in beta-hemolytic streptococci (BHS) from problem mares, highlighting persister cells that tolerate penicillin at 10,000 times the normal MIC. Using bActivate, dormant BHS were reactivated and successfully treated.
This document provides scientific and practical evidence supporting the use of bActivate for diagnosing and treating latent endometritis in problem mares. The study highlights the reactivation of dormant Streptococcus equi subsp. zooepidemicus infections.
Real results from veterinarians and breeders who have made bActivate part of their reproductive protocol.
“We incorporated bActivate into our standard reproductive work-up for problem mares at Hagyard. Out of 64 mares that had failed to conceive for at least 3 cycles, 83% became pregnant following bActivate activation and targeted antibiotic treatment. Nearly half had a dormant Streptococcus infection that standard culture had completely missed. It changed the way we approach the problem mare.”
“We used bActivate on 19 of our most persistent problem mares — horses that had been barren for over a year despite every conventional treatment we tried. 89% of them got in foal. What really opened our eyes was how many had a hidden infection that standard swabs had never detected. It is now a routine part of our protocol at Kildangan.”
“We have been using bActivate on several mares — all got pregnant and most of them in first try with frozen semen!”
“bActivate is an excellent tool that allows us as reproductive vets to do our job as effectively as possible. When you compare the cost to the expense of a mare that fails to conceive — or worse, never produces a foal — bActivate is both a smart and cost-effective solution in the long run.”
“I used bActivate and after just one covering got a colt foal — after 3 years of hardship where the mare went in foal but never managed to produce a live foal. I cannot recommend bActivate enough.”
FAQ
Common questions about problem mares, biofilm infections and bActivate treatment.